Professor Edmund T. Rolls' Publication List by Subject
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Citations   (see also Citations and impact)

Brain and Mental Disorders

Shen,C., Rolls, E. T., Xiang,S., Langley,C., Sahakian,B.J., Cheng,W. and Feng,J. (2023) Brain and molecular mechanisms underlying the nonlinear association between close friendships, mental health, and cognition in children. eLife 12: e84072.
Rolls, E. T., Feng,R and Feng,J. (2023) Lifestyle risks associated with brain functional connectivity and structure. Human Brain Mapping 44: 2479-2492. doi: 10.1002/hbm.26225. Supplementary Material
Linli,Z., Rolls, E. T., Zhao,W., Kang,J., Feng,J. and Guo,S. (2023) Smoking is associated with lower brain volume and cognitive differences: A large population analysis based on the UK Biobank. Progress in Neuropsychopharmacology and Biological Psychiatry 123: 110698.  doi: 10.1016/j.pnpbp.2022.110698.
Zhang,J., Yao,Y., Wu,J., Rolls, E. T., Sun,C., Bu,L., Lu,J., Lin,C-P., FengJ., Mao, Y. and Zhou,L. (2023) The cortical regions and white matter tracts underlying auditory comprehension in patients with primary brain tumor. Human Brain Mapping 44: 1603-1616. doi: 10.1002/hbm.26161.
Wang,H-F., Zhang,W., Rolls, E. T., Alzheimer's Disease Neuroimaging Initiative, Li,Y., Wang,L., Ma,Y-H., Kang,J., Feng,J., Yu,J-T. and Cheng,W. (2022) Hearing impairment is associated with cognitive decline, brain atrophy and tau pathology. eBioMedicine 86: 104336.
Ma,Q., Wang,H., Rolls, E. T., Xiang,S., Li,J., Li,Y., Zhou,Q., Cheng,W., Li,F. (2022) Lower gestational age is associated with lower cortical volume and cognitive and educational performance in adolescence. BMC Medicine 20: 424.
Chen,S.D., Zhang,W., Li,Y-Z., Yang,L., Huang,Y-Y., Deng,Y-T., Wu,B-S., Suckling,J., Rolls, E. T., Feng,J., Cheng,W., Dong,Q. and Yu,J-T. (2023) A phenome-wide association and Mendelian randomization study for Alzheimer’s disease: a prospective cohort study of 502,493 participants from UK Biobank. Biological Psychiatry 93: 790-801.  doi: 10.1016/j.biopsych.2022.08.002.
Huang,S-Y., Li,Y-Z., Zhang,Y-R., Wu,B-S., Zhang,W.,  Deng,Y-T., Chen,S-D., He,X-Y., Chen, S-F., Dong,Q., Zhang,C., Chen,R-J., Suckling,J., Rolls, E. T., Feng,J., Cheng,W. and Yu,J-T. (2022) Sleep, physical activity, sedentary behavior, and risk of incident dementia: a prospective cohort study of 431,924 UK Biobank participants. Molecular Psychiatry 27: 4343-4354. doi: 10.1038/s41380-022-01655-y
Yang,A.C., Rolls, E. T., Dong,G., Du,J., Li,Y., Feng,J., Cheng,W. and Zhao,X-M. (2022) Longer screen time utilization is associated with the polygenic risk for Attention-deficit / hyperactivity disorder with mediation by brain white matter microstructure. EBioMedicine 80: 104039.  doi: 10.1016/j.ebiom.2022.104049.
Wan,Z, Rolls, E. T., Feng,J. and Cheng,W. (2022) Brain functional connectivities that mediate the association between childhood traumatic events, and adult mental health and cognition. EBioMedicine 79: 104002.  doi: 10.1016/j.ebiom.2022.104002.
Shen,S., Rolls, E. T., Cheng,W., Kang,J., Dong,G., Xie,C., Zhao,X-M., Sahakian,B. and Feng,J. (2022) Associations of social isolation and loneliness with later dementia. Neurology 99: e164-e175. doi: 10.1212/WNL.0000000000200583.
Wang,L., Zhou,C., Cheng,W., Rolls, E. T., Huang,P., Ma,N., Liu,Y., Zhang,Y., Guan, X., Guo,T., Wu,J., Gao,T., Xuan,M., Gu,Q., Xu,X., Zhang,B., Gong,W., Du,J., Zhang,W., Feng,J., and Zhang,M. (2022) Dopamine depletion and subcortical dysfunction disrupt cortical synchronization and metastability affecting cognitive function in Parkinson’s disease. Human Brain Mapping 43: 1598-1610. doi: 10.1002/hbm.25745.
Du,J, Rolls, E. T., Gong,W., Cao,M., Vatansever,D., Zhang,J., Kang, J., Cheng,W. and Feng,J. (2022) Association between parental age, brain structure, and behavioral and cognitive problems in children. Molecular Psychiatry 27: 967-975. doi: 10.1038/s41380-021-01325-5.
Rolls, E. T. (2021) The neuroscience of emotional disorders. Chapter 1 in Handbook of Clinical Neurology 183: 1-26 Disorders of Emotion in Neurologic Disease, Eds. K.M.Heilman and S.E.Nadeau. Elsevier: Oxford.

Gong,W., Rolls, E. T., Du,J., Feng,J. and Cheng,W. (2021) Brain structure is linked to the association between family environment and behavioral problems in children in the ABCD study. Nature Communications 12: 3769. doi: 10.1038/s41467-021-23994-0. Supplementary Material

Rolls, E. T. (2021) Attractor cortical neurodynamics, schizophrenia, and depression. Translational Psychiatry 11: 215. doi: 10.1038/s41398-021-01333-7.

Rolls, E. T., Cheng,W. and Feng,J. (2021) Brain dynamics: the temporal variability of connectivity, and differences in schizophrenia and ADHD. Translational Psychiatry 11: 70. doi: 10.1038/s41398-021-01197-x.

He,L., Wei,D., Yang,F., Zhang,J., Cheng,W., Yang,W., Zhuang,K., Chen,Q., Ren,Z., Li,Y., Wang,X., Mao,Y., Chen,Z., Liao,M., Cui,H., Li,C., He,Q., Lei,X., Feng,T., Chen,H., Xie,P., Rolls, E. T., Feng,J., Su,L., Li,L. and Qiu,J. (2021) Functional connectome prediction of anxiety related to the COVID-19 pandemic. American Journal of Psychiatry 178: 530-540. doi: 10.1176/appi/ajp.2020.20070979.

Rolls,E.T., Cheng,W. and Feng,J. (2020) The orbitofrontal cortex: reward, emotion, and depression. Brain Communications 2: fcaa196.

Feng,R., Rolls, E. T., Cheng,W. and Feng,J. (2020) Hypertension is associated with reduced hippocampal connectivity and impaired memory. EBioMedicine 61: 103082. Supplementary Material

Xie,C., Jia,T., Rolls, E. T. et al (2021) Reward vs non-reward sensitivity of the medial vs lateral orbitofrontal cortex related to the severity of depressive symptoms. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 6: 259-269. Supplementary Material

Wang,H., Rolls, E. T., Du,X., Du,J., Yang, D. Li,J., Li,F., Cheng,W. and Feng,J. (2020) Severe nausea and vomiting in pregnancy: psychiatric and cognitive problems, and brain structure in children. BMC Medicine 18: 228.  Supplementary Material

Wang,L., Cheng,W., Rolls, E. T., Dai,F., Gong,W., Du,J., Zhang,W., Wang,S., Liu,F., Wang,J., Brown,P. and Feng,J. (2020) Association of specific biotypes in patients with Parkinson disease and disease progression. Neurology 95: e1445-e1460.

Cheng,W., Rolls, E. T., Gong,W., Du,J., Zhang,J., Zhang,X., Li,F. and Feng,J. (2021) Sleep duration, brain structure, and psychiatric and cognitive problems in children. Molecular Psychiatry 26: 3992-4003. Press Release Supplementary Material

Rolls, E. T., Cheng,W., Du,J., Wei,D., Qiu,J., Dai,D., Zhou,Q., Xie, P. and Feng, J. (2020) Functional connectivity of the right inferior frontal gyrus and orbitofrontal cortex in depression. Social Cognitive and Affective Neuroscience 15: 75-86. Supplementary Material

Rolls, E. T. (2019) Attractor network dynamics, transmitters, and the memory and cognitive changes in aging. Chapter 14 pp 203-225 in Cognitive Changes and the Aging Brain, Eds. K.M.Heilman and S.E.Nadeau. Cambridge University Press: Cambridge. doi: 10.1017/9781108554350.

Rolls, E. T., Zhou, Y., Cheng,W., Gilson,M., Deco,G. and Feng,J. (2020) Effective connectivity in autism. Autism Research 13: 32-44.

Rolls, E. T., Cheng,W., Gilson,M., Gong,W., Deco,G., Zac Lo,C-Y., Yang,A.C., Tsai,S-J., Liu,M-E., Lin,C-P. and Feng,J. (2020) Beyond the disconnectivity hypothesis of schizophrenia. Cerebral Cortex 30: 1213-1233.

Cheng,W., Rolls, E. T., Robbins,T.W., Gong,W., Liu,Z., Lv,W., Du,J., Wen,H., Ma,L., Burke Quinlan,E., Garavan,H., Artiges,E., Papadopoulos Orfanos,D., Smolka,M.N., Schumann,G., Kendrick,K. and Feng,J. (2019) Decreased brain connectivity in smoking contrasts with increased connectivity in drinking. eLife 8: e40765. doi: 10.7554/eLife.40765. Summary. Press Release. Podcast in part 2.

Ma, L., Rolls, E. T., Liu, X., Liu, Y., Jiao, Z., Wang, Y., Gong, W., Ma, Z., Gong, F., and Wan, L. (2019) Multi-scale analysis of schizophrenia risk genes, brain structure, and clinical symptoms reveals integrative clues for subtyping schizophrenia patients. Journal of Molecular Cell Biology 11: 678-687.

Rolls, E. T., Cheng, W., Gong, W., Qiu, J., Zhou, C., Zhang, J., Lv, W., Ruan, H., Wei, D., Cheng, K., Meng, J., Lin, C. P., Xie, P. and Feng, J. (2019) Functional connectivity of the anterior cingulate cortex in depression and in health. Cerebral Cortex 29: 3617-3630. Supplementary Material.

Cheng, W., Rolls, E. T., Qiu, J., Yang, D., Ruan, H., Wei, D., Zhao, L., Meng, J., Xie, P. and Feng, J. (2018) Functional connectivity of the precuneus in unmedicated patients with depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3: 1040-1049.

Cheng, W., Rolls, E. T., Ruan, H. and Feng, J. (2018) Functional connectivities in the brain that mediate the association between depressive problems and sleep quality. JAMA Psychiatry 75: 1052-1061. Supplementary Material.

Cheng, W., Rolls, E. T., Qiu, J., Xie, X., Lyu, W., Li, Y., Huang, C. C., Yang, A. C., Tsai, S. J., Lyu, F., Zhuang, K., Lin, C. P., Xie, P. and Feng, J. (2018) Functional connectivity of the human amygdala in health and in depression. Social, Cognitive, and Affective Neuroscience 13: 557-568.

Cheng, W., Rolls, E. T., Qiu, J., Xie, X., Wei, D., Huang, C-C., Yang, A. C., Tsai, S.-J., Li, Q., Meng, J., Lin, C.-P., Xie, P. and Feng, J. (2018) Increased functional connectivity of the posterior cingulate cortex with the lateral orbitofrontal cortex in depression. Translational Psychiatry 8: 90.

Rolls, E. T., Cheng,W., Gilson,M., Qiu,J., Hu,Z., Ruan,H., Li,Y., Huang,C-C., Yang,A.C., Tsai,S-J., ZhangX., Zhuang,K., Lin,C-P., Deco,G., Xie,P., Feng,J. (2018) Effective connectivity in depression. Biological Psychiatry: Cognitive Neuroscience and Neuroimaging 3: 187-197. Supplementary Material. Press release.

Rolls, E. T., Lu,W., Wan,L., Yan,H., Wang,C., Yang,F., Tan,Y.L., Li,L., Chinese Schizophrenia Collaboration Group, Yu,H., Liddle,P.F., Palaniyappan,L., Zhang,D., Yue,W. and Feng,J. (2017). Individual differences in schizophrenia. British Journal of Psychiatry Open 3: 265–273. doi: 10.1192/bjpo.bp.117.0050. Supplementary Material.

Rolls, E. T. (2019) The orbitofrontal cortex and emotion in health and disease, including depression. Neuropsychologia 128: 14-43.

Rolls, E.T. (2017) The roles of the orbitofrontal cortex via the habenula in non-reward and depression, and in the responses of serotonin and dopamine neurons. Neuroscience and Biobehavioral Reviews 75: 331-334.

Cheng,W., Rolls,E.T., Zhang,J., Sheng,W., Ma,L., Wan,L., Luo,Q. and Feng,J. (2017) Functional connectivity decreases in autism in emotion, self, and face circuits identified by Knowledge-based Enrichment Analysis. Neuroimage 148: 169-178.

Cheng, W., Rolls,E.T., Qiu,J., Liu,W., Tang,Y., Huang,C-C., Wang, XF., Zhang,J., Lin,W., Zheng,L., Pu, JC., Tsai,S-J., Yang,AC., Lin,C-P., Wang,F., Xie,P. and Feng,J. (2016) Medial reward and lateral non-reward orbitofrontal cortex circuits change in opposite directions in depression. Brain 139: 3296-3309. Supplementary Material.

Li,T., Wang,Q., Zhang,J., Rolls, E. T., Yang,W., Palaniyappan,L., Zhang,L., Cheng,W., Yao,Y., Liu,Z., Gong,X., Luo,Q., Tang,Y., Crow,T.J., Broome, M.R., Xu,K., Li,C., Wang,J., Liu,Z.,Lu,G., Wang,F. and Feng,J. (2017) Brain-wide analysis of functional connectivity in first-episode and chronic stages of schizophrenia. Schizophrenia Bulletin 43: 436-448.

Rolls, E. T. (2016) A non-reward attractor theory of depression. Neuroscience and Biobehavioral Reviews 68: 47-58.

Rolls,E.T., Kellerhals,M.B. and Nichols,T.E. (2015) Age differences in the brain mechanisms of good taste. Neuroimage 113: 298-309.

Rolls, E. T. (2015) Taste, flavor, and appetite. Pp 573-580 in Brain Mapping: An Encyclopedic Reference, vol 2, Ed. A.Toga. Academic Press / Elsevier: Amsterdam.

Rolls, E. T. (2015) Taste, olfactory, and food reward value processing in the brain. Progress in Neurobiology 127-128: 64-90.

Cheng,W., Rolls,E.T., Gu, H., Zhang,J. and Feng,J. (2015) Autism: reduced connectivity between cortical areas involved in face expression, theory of mind, and the sense of self. Brain 138: 1382-1393. Supplementary Material.

Rolls, E.T. and Deco, G. (2015) Stochastic cortical neurodynamics underlying the memory and cognitive changes in aging. Neurobiology of Learning and Memory 118: 150-161.

Kesner,R.P. and Rolls,E.T. (2015) A computational theory of hippocampal function, and tests of the theory: new developments. Neuroscience and Biobehavioral Reviews  48: 92-147.

Pu, W., Rolls, E. T., Guo, S., Liu, H., Yu, Y., Xue, Z., Rolls, E. T., Feng, J. and Liu, Z. (2014) Altered functional connectivity links in neuroleptic-naďve and neuroleptic-treated patients with schizophrenia, and their relation to symptoms including volition. Neuroimage Clinical  6: 463-474.

Gallo,M. Gámiz,F., Perez-García,M., del Moral,R.G. and Rolls, E. T. (2014) Taste and olfactory status in a gourmand with a right amygdala lesion. Neurocase: The Neural basis of Cognition 20: 421-433. 

Millan MJ, Agid Y, Brüne M, Bullmore ET, Carter CS, Clayton NS, Connor R,Davis S, Deakin R, De Rubeis RJ, Dubois B, Geyer MA, Goodwin GM, Gorwood P, Jay TM, Mansuy IM, Meyer-Lindenberg A, Murphy D, Rolls ET, Saletu B, Spedding M, Sweeney J, Whittington M and Young LJ. (2012) Cognitive dysfunction in psychiatric disorders: characteristics, causes and the quest for improved therapy. Nature Reviews Drug Discovery 11: 141-168.

Rolls,E.T. (2012) Glutamate, obsessive-compulsive disorder, schizophrenia, and the stability of cortical attractor neuronal networks. Pharmacology, Biochemistry and Behavior 100: 736-751.

Rolls,E.T., Deco,G. and Winterer,G. (2011) A computational neuroscience approach to schizophrenia: working memory and attentional deficits. Archives of General Psychiatry:

Rolls,E.T. and Deco,G. (2011) A computational neuroscience approach to schizophrenia and its onset. Neuroscience and Biobehavioral Reviews 35: 1644-1653.
Rolls,E.T., Loh,M., Deco,G. and Winterer,G. (2008) Computational models of schizophrenia and dopamine modulation in the prefrontal cortex. Nature Reviews Neuroscience 9: 696-709.
Rolls,E.T., Loh,M. and Deco,G. (2008) An attractor hypothesis of obsessive-compulsive disorder. European Journal of Neuroscience 28: 782-793.
Loh,M., Rolls,E.T. and Deco,G. (2007) Statistical fluctuations in attractor networks related to schizophrenia. Pharmacopsychiatry 40: S78-84.
Loh,M., Rolls,E.T. and Deco,G. (2007) A dynamical systems hypothesis of schizophrenia. PLoS Computational Biology 3(11): e228. doi:10.1371/journal.pcbi.0030228
Berlin,H., Rolls, E.T., and Iversen,S.D. (2005) Borderline Personality Disorder, impulsivity, and the orbitofrontal cortex. American Journal of Psychiatry 162: 2360-2373.
Berlin,H., and Rolls, E.T. (2004) Time perception, impulsivity, emotionality, and personality in self-harming Borderline Personality Disorder patients. Journal of Personality Disorders 18: 358-378.
Kadohisa,M., Rolls,E.T. and Verhagen,J.V. (2004) Orbitofrontal cortex neuronal representation of temperature and capsaicin in the mouth. Neuroscience 127: 207-221.
Deco,G., Rolls,E.T., and Horwitz,B.(2004) “What” and “where” in visual working memory: a computational neurodynamical perspective for integrating fMRI and single-neuron data. Journal of Cognitive Neuroscience 16: 683-701.
O’Doherty,J., Rolls,E.T. and Kringelbach,M.L. (2004) Neuroimaging studies of crossmodal integration for emotion. Ch. 35, pp. 563-579 in: The Handbook of Multisensory Processes. Eds. G.Calvert, C.Spence and B.E.Stein. MIT Press: Cambridge, MA.
Rolls,E.T. (2004) Multimodal neuronal convergence of taste, somatosensory, visual, olfactory and auditory inputs. Ch. 19, Pp. 311-331 in: The Handbook of Multisensory Processes. Eds. G.Calvert, C.Spence and B.E.Stein. MIT Press: Cambridge, MA.
Rolls,E.T. (2004) The functions of the orbitofrontal cortex. Brain and Cognition 55: 11-29.
Kringelbach,M.L. and Rolls,E.T. (2004) The functional neuroanatomy of the human orbitofrontal cortex: evidence from neuroimaging and neuropsychology. Progress in Neurobiology 72: 341-372.
Rolls, E.T. (2004) A higher order syntactic thought (HOST) theory of consciousness. Ch 7, pp. 137-172 in Higher Order Theories of Consciousness. Ed. R.J.Gennaro. John Benjamins: Amsterdam/Philadelphia.
Hornak, J., O’Doherty, J, Bramham, J., Rolls, E.T., Morris, R.G., Bullock,P.R. and Polkey, C.E. (2004). Reward-related reversal learning after surgical excisions in orbitofrontal and dorsolateral prefrontal cortex in humans. Journal of Cognitive Neuroscience 16: 463-478.
Berlin,H., Rolls, E.T., and Kischka,U. (2004) Impulsivity, time perception, emotion, and reinforcement sensitivity in patients with orbitofrontal cortex lesions. Brain, 127: 1108-1126.


Hornak,J., Rolls,E.T. and Wade,D. (1996) Face and voice expression identification in patients with emotional and behavioural changes following ventral frontal lobe damage. Neuropsychologia 34: 247-261.


Rolls,E.T., Hornak,J., Wade,D. and McGrath,J. (1994) Emotion-related learning in patients with social and emotional changes associated with frontal lobe damage. Journal of Neurology, Neurosurgery and Psychiatry 57: 1518-1524.